Do house edition interventions assist in reducing crisis fall admission? A national longitudinal dat

Author : Marcus Bowling | Published On : 28 Apr 2025

OBJECTIVE This study aimed to assess early mortality (within 1 and 3 months) in patients with primary central nervous system lymphoma (PCNSL) and to identify risk factors associated with early mortality. METHODS We extracted data of PCNSL patients from the Surveillance, Epidemiology, and End Results (SEER) dataset by using the SEER*Stat 8.3.5 software. RESULTS A total of 8091 patients with PCNSL were enrolled in this study. Among them, 57.94% were male, and 42.06% were female. The mean age was 59.50±16.11 years. Death within 1 and 3 months was 10.67% and 29.16%, respectively. Over the past 20 years, early mortality has declined significantly. The common causes of early death were non-Hodgkin lymphoma and other infectious and parasitic diseases, including HIV. Our results showed that gender, age at diagnosis, ethnicity, histological subtype, marital status, tumor location, surgery, radiation, and chemotherapy were associated with early mortality within 1 or 3 months. CONCLUSION The early mortality has declined significantly over the past 20 years. A-1155463 research buy Risk factors for early mortality within 1 or 3 months after PCNSL diagnosis included advanced age, male gender, black race, frontal lobe, unmarried, diffuse large B-cell lymphoma, no surgery, no chemotherapy, and no radiotherapy. BACKGROUND Percutaneous endoscopic surgery is a popular surgery to treat lumbar spinal disorders. However, seizure following percutaneous endoscopic surgery is an unpredictable complication. The only prodromal sign for seizure currently known is neck pain. OBJECTIVES To review incidence, risk factors of seizure during percutaneous endoscopic surgery. To present three cases with seizure and our management. METHODS From October 2006 to March 2019, three of 816 patients (0.34%) with thoracic lumbar disorders who had received percutaneous endoscopic surgery experienced a seizure episode. Those three cases were carefully reviewed. Articles on risk factors for seizure following the spinal procedures published before 06/13/2019 were identified through a PubMed search. RESULTS We observed the infusion fluid containing cefazolin, infusion rate, prolonged surgery time, dura tear, and sevoflurane anesthesia may be associated with the seizure attack as described in the literature. Three patients who experienced a seizure episode were under general anesthesia with sevoflurane, and the surgical approach used was interlaminar for herniated disc in L5-S1. We noticed a red flag sign, namely an uncontrollable hypertension episode combined with decreasing pulse rate, in all patients who experienced seizure, which was not observed in other patients. All three patients received antihypertensive medication (labetalol) three times or more without response. CONCLUSION Seizure following percutaneous endoscopic surgery is rare but lethal. Although it's cause remain unknown, we should check all risk factors for seizure and corrected immediately when a red flag sign, uncontrolled hypertension, appears. OBJECTIVES This study aims to summarize the clinical characteristics of death cases with COVID-19 and to identify critically ill patients of COVID-19 early and reduce their mortality. METHODS The clinical records, laboratory findings and radiological assessments included chest X-ray or computed tomography were extracted from electronic medical records of 25 died patients with COVID-19 in Renmin Hospital of Wuhan University from Jan 14 to Feb 13, 2020. Two experienced clinicians reviewed and abstracted the data. RESULTS The age and underlying diseases (hypertension, diabetes, etc.) were the most important risk factors for death of COVID-19 pneumonia. Bacterial infections may play an important role in promoting the death of patients. Malnutrition was common to severe patients. Multiple organ dysfunction can be observed, the most common organ damage was lung, followed by heart, kidney and liver. The rising of neutrophils, SAA, PCT, CRP, cTnI, D-dimer, LDH and lactate levels can be used as indicators of disease progression, as well as the decline of lymphocytes counts. CONCLUSIONS The clinical characteristics of 25 death cases with COVID-19 we summarized, which would be helpful to identify critically ill patients of COVID-19 early and reduce their mortality. OBJECTIVES This study aimed to verify the frequency, genotypes and etiological role of Human Bocavirus (HBoV) in younger Amazonian children with either acute gastroenteritis (AGE) or respiratory infections (ARI). The influence of Rotarix™ vaccination and co-infection status was investigated. DESIGN HBoV quantitative polymerase chain reaction (qPCR) testing of both fecal and saliva (1468 samples) from 734 children less then 5 months old living in the Amazon (Brazil, Guyana and Venezuela). High and median HBoV viral load samples were used for extraction, nested PCR amplification and sequencing for genotyping. HBoV mRNA detection was done by reverse transcription following DNA amplification. RESULTS The overall HBoV frequencies were 14.2% (69/485; AGE) and 14.1% (35/249; ARI) (p =  0.83). HBoV exclusively infected 4.5% (22/485; AGE) and 4% (10/249) of the Amazonian children (Odds ratios 1.13, 95% confidence interval= 2.42-0.52). HBoV 1 was mainly detected in feces and saliva from AGE children; and HBoV2, from ARI children. HBoV mRNA was detected only in feces. The Rotarix™ vaccination status did not affect the HBoV frequencies. CONCLUSIONS We suggested that, after entry into the air/oral pathways, HBoV1 continues infecting towards the intestinal tract causing AGE. HBoV2 can be a causative agent of AGE and ARI in younger Amazonian children. OBJECTIVES The China-Laos border has been identified as an important origin of imported malaria outside China. The aim of this study was to describe the asymptomatic malaria infections and epidemic trend of malaria in China-Laos border region. METHODS A prevalence survey and surveillance of mosquito vectors was conducted in Muang Khua District of Phongsaly Province, China-Laos border, to determine the parasite carrying rate using nested PCR and microscopy and the species composition of malaria vectors by overnight trapping. Blood samples were collected from 354 local residents aged 1-72 years in Sankang village in 2016. A total of 2430 adult mosquitoes were collected from other 4 villages in Muang Khua District from June to August 2016. RESULTS The parasite-carrying rate was 7.63% (27/354) by microscopy or 7.91% (28/354) by nested PCR. The surveillance results of mosquito vectors revealed the predominant genera of adult mosquitoes were Culex (69.92%, 1699/2430) and Anopheles (21.48%, 522/2430). Anopheles sinensis (82.