Person and also put together connection between anticancer drugs in freshwater rotifers: A multigene

Author : Joyner Bender | Published On : 21 Feb 2025

The Swan Lagoon is a national nature reserve and an important spawning ground in China. click here In this study, we evaluated the concentration of heavy metals (Cd, Cr, Cu, Pb, and Zn) in different aquatic organisms (aquatic plants, crustaceans, mollusks, and fish), in order to examine their trophic transfer in food web. The results showed that the concentrations of Cd, Cu, Pb, and Zn were considerably higher in mollusks, whereas Cr concentrations were significantly higher in aquatic plants than in mollusks, crustaceans, and fish (p 0.05), indicating neither biomagnification or biodilution in the food web.Decabromodiphenyl ether (BDE-209) is a persistent environmental pollutant that poses great risks to human health and has been associated with glucose and lipid metabolism. However, the mechanisms by which BDE-209 disturbs glycolipid metabolism in the liver remain unclear. Therefore, this study sought to confirm the effects of BDE-209 on glycolipid metabolism in mice livers and L02 cells to elucidate potential mechanisms of action. In vivo BDE-209 exposure caused histological damage and lipid accumulation, elevated glucose, low-density lipoprotein, total cholesterol, and triglyceride levels, and decreased glycogen and high-density lipoprotein levels in mice livers. Moreover, in vitro BDE-209 exposure not only induced L02 cells cytotoxicity (i.e., reduced cell viability and increased LDH leakage and ROS generation) but also increased glucose and triglyceride concentrations in L02 cells. Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4. Moreover, GW9662, a PPARγ inhibitor, blocked lipid accumulation and the upregulation of the mTOR/PPARγ/RXRα pathway in L02 cells induced by BDE-209 by relieving the increases in p-mTOR, PPARγ, and RXRα protein expression levels. In summary, this study revealed that BDE-209 disrupted glycolipid metabolism by inhibiting the PI3K/AKT/GLUT4 pathway and activating the mTOR/PPARγ/RXRα pathway.The purpose of the present investigation is to examine the physicomechanical properties and the hydration development of ternary blended cements, composed by waste marble dust (WMD) and soda lime recycled glass (SLRG). Both wastes characteristics were investigated by means of chemical analysis, laser particle size analyzer and X-ray diffraction (XRD). Prior to their addition as substitutes for Ordinary Portland Cement (OPC), they were grounded to a specific surface area of 4000 cm2/g. Twelve different cement mixtures were produced, containing up to 20% of the above-mentioned wastes, in various proportions. The produced cements mixtures were evaluated, examining their setting times, standard consistency, soundness and compressive strength at 2, 7, 28, 56 and 90 days. The resistance to the alkali-silica reaction of the cement mixtures contained SLRG and the corresponding expansion was determined in prismatic mortar bars, at 38 °C, after 14, 28, 60, 90 and 180 days. The determination of their hydration evolution was accomplished by X-ray diffraction and thermogravimetric and differential thermal (TG/DTG) analyses. According to the results, WMD could be readily valorized together with SLRG as cementitious additions for cement replacement.The study aimed at evaluating the nitrogen removal performance of the immobilized denitrification filler, and the influence of shock loading on the high-rate denitrification process. A pilot scale reactor was operated for treatment of aniline production wastewater. The nitrogen removal activity significantly increased in the continuous feed experiments, reaching 5.23 kg N m-3 day-1 on day 31 (30 °C) at Hydraulic Retention Time (HRT) = 10 h. In the impact experiment, the denitrification filler was inhibited by Free Nitrite Acid (FNA) when the shock load flowed 1.5 times into the bioreactor and recovered after the load was restored for 20 h. The high-throughput results demonstrated that the dominant position of the denitrifying bacteria further enhanced in a micro toxic and high-salinity environment, providing a basis for the dominance of the composite denitrifying bacteria and the efficacy of the immobilization technology.Mangrove forests cover only 0.1% of the world's continental area; however, these are a substantial carbon sink owing to the high primary production and low rate of decomposition of soil organic matter (SOM). The extremely low decomposition rate of SOM in mangrove forests is believed to be caused by low oxygen and nutrient availability as well as recalcitrant biomass from mangrove. However, only a few studies have addressed the microbial mechanism that plays a key role in the decomposition of SOM. In this study, the decomposition of SOM were determined by conducting a field survey and an lab incubation experiment using soil samples from mangrove forests in three regions; Okinawa, Shenzhen, and Hong Kong. In particular, we examined the occurrence of the enzymic latch mechanism, which involves phenolic inhibition of enzymic decomposition, in mangrove forest soils that highlights the importance of phenol oxidase as a key controlling factor. The results clearly showed that enzymic latch involved in the accumulation of SOM in the mangroves of Shenzhen and Hong Kong, whereas the accumulation of SOM in Okinawa was controlled by other mechanisms, such as the iron gate mechanism, which involves stabilization of soil carbon in iron-SOM complexes. The characteristics of mangrove forests, such as iron concentration, were shown as substantial determination factors in the dynamics of SOM. We concluded that the decomposition of SOM were strongly affected by the characteristics of mangrove forests, and the occurrence of enzymic latch in mangrove forests has a potential application in geoengineering technology to enhance the carbon sequestration capacity of mangrove forests.Urban waterlogging is a hydrological cycle problem that seriously affects people's life and property. Characterizing waterlogging variation and explicit its driving factors are conducive to prevent the damage of such disasters. Conventional methods, because of the high spatial heterogeneity and the non-stationary complex mechanism of urban waterlogging, are not able to fully capture the urban waterlogging spatial variation and identify the waterlogging susceptibility areas. A more robust method is recommended to quantify the variation trend of urban waterlogging. Previous studies have simulated the waterlogging variation in relatively small areas. However, the relationship between variables is often ignored, which cannot comprehensively reveal the dominant drivers affecting urban waterlogging. Therefore, a novel approach is proposed that combined stepwise cluster analysis model (SCAM) and hierarchical partitioning analysis (HPA) within a general framework and verifies the applicability through logistic regression, artificial neural network, and support vector machine.