Organoids And Spheroids Market: Dynamics Trends, Statistics, Segments Growth Factors Forecast to 203

Author : Mrudula Karmarkar | Published On : 25 Jan 2024

San Francisco, 25 January 2024: The Report Organoids And Spheroids Market Size, Share & Trends Analysis Report By Type (Neurospheres, iPSCs Derived Cells, Hepatic Organoids), By Application, By End Use, By Region, And Segment Forecasts, 2020 - 2027

The global organoids and spheroids market size is expected to reach USD 2.1 billion by 2027, according to a new report by Grand View Research, Inc., expanding at a CAGR of 22.5% over the forecast period. A rise in the adoption of organoid cultures in drug discovery, and rising demand for cell therapy and tissue engineering across the globe is expected to drive the market.

3D spheroids are considered as an important aspect of tissue engineering and regenerative medicine research as they can be used as building blocks for the generation of complex tissues and organs. In addition, the potential of 3D cell cultures to be used as models for drug screening and analysis of human disorders are expected to provide ample growth opportunities to the market in the near future.

A rise in the adoption of organoid cultures for the assessment of the mechanism of human-specific disorders is expected to enhance the market growth. For instance, human organoids have helped in the analysis of a wide range of tissues including the small intestine, prostate, brain, and liver. The promise of the generation of 3D cell cultures that resemble human organs has brought an enormous potential for the use of organoids as cell therapies, and as prospective substitutes for whole-organ transplantation.

Usage of the organoid models to reveal, how the COVID-19 virus affects several intestinal cells is expected to drive the adoption of organoids in research. Scientists have been using these systems for the testing and identification of promising medications. Companies are engaged in the development and launch of products well before the COVID-19 pandemic. For instance, Agilent Technologies has developed a spheroid microplate that facilitates cellular energy metabolism measurement in 3D cell culture spheroids with the help of a Seahorse XF analyzer. The Seahorse XFe96 Spheroid Microplates developed by the company measures glycolysis and respiration within the 3D cell cultures. Similarly, Corning Incorporated launched HTS Transwell tissue culture systems and spheroid microplates for high-throughput culturing.

The organoids segment is expected to grow with a lucrative rate as organoids can potentially be used as in-vitro models for drug discovery. MatTek Corporation has cultured 3D organotypic structures for the production and commercialization of in vitro human tissue models. The company has commercialized bronchial airway (EpiAirway), skin (EpiDerm, EpiDermFT), vaginal (EpiVaginal), and ocular (EpiOcular) epithelium.

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Technological developments in the 3D spheroid technology are expected to drive the market at a significant rate. For instance, the Cultrex Organoid Progenitor Cells introduced by AMS Biotechnology (AMSBIO) can be optimized by the use of different sets of extracellular matrices. Such developments facilitate the researchers to direct the activities of cells by controlling the culture microenvironment. Cultrex spheroid proliferation/viability and invasion assays offered by the company stimulate the development of cohesive spheroids even in low adhesion environments.

Organoids And Spheroids Market Report Highlights

• The spheroids segment is anticipated to dominate the market throughout the analysis period
• Higher adoption of 3D spheroids in the fields of drug discovery, disease modeling, and safety testing is a key factor driving the segment
• The developmental biology application segment accounted for the largest revenue share in 2020 as the development of organoids from Induced Pluripotent Stem Cells (iPSCs) have paved way for dynamic observation of cell development and propelled the adoption of mechanistic studies for human development
• Biotechnology and pharmaceutical industries dominated the end-use segment in the market in 2020. This is because of the high utilization rate of organoids and spheroids in pre-clinical drug discovery by pharma entities
• In addition, these players are actively involved in the development of advanced products that enhance the efficiency of organoid and spheroid generation.
• For instance, In December 2018, Sun Bioscience developed a robotic platform specially designed for the production of organoids for personalized medicine. The platform facilitates automated image-based screening of such cells
• In North America, the market generated the highest revenue in 2020 due to higher adoption of technologically advanced cell culture platforms, and the presence of a large number of universities and academic institutions actively involved in cell and organ-based studies
• In addition, a higher adoption rate of organoid and spheroid culture products and efficient healthcare infrastructure in North America is attributive to the largest revenue generation from the region
• In Asia Pacific, the market is anticipated to witness lucrative growth over the forecast period.
• Presence of key players and government organizations such as STEMCELL Technologies, Australasian Society for Stem Cell Research (ASSCR), The Japanese Society for Regenerative Medicine, The Korean Society for Stem Cell Research (KSSCR), and others are expected to enhance the penetration of organoid and spheroid culture in Asia
• The key players are constantly involved in research and development of new products so that they can enhance their market position.

The spheroids produced by this technique have been embedded in an invasion matrix and are used for the modeling of cell invasion from tumor spheroids. Researchers have further developed a 3D tri-culture model by adding vascular cells and human mesenchymal stem cells (hMSCs) to these spheroids. These efforts have led to the development of a predictive in-vitro model as the tri-cultures exhibit drug response and tumor morphology similar to xenografts. Such studies have propelled the adoption of spheroids and organoids.

Similarly, the Nano Culture Plate (NCP) and Nano Culture Dish (NCD) developed by SCIVAX Corporation are applicable for high throughput screening (HTS). Moreover, spheroids grown on NCP can be used for live imaging under both fluorescence and bright-field microscopes. Therefore, these plates are now utilized for the development of several assays that were previously difficult to develop by using other 3D and monolayer cell culture systems.

Organoids And Spheroids Market Report Scope

Spheroids are commonly generated from cell lines, whereas stem cells are the preferred cell source for culturing organoids. The commercial availability of cell lines for spheroid generation is a major factor for the high revenue share of the segment. LNCaP Cell Line and PC-3 Cell Line are some of the commonly used products for a spheroid generation.

Competition among the existing players has increased owing to developments in technology and its potential applications in the arena of drug discovery. Therefore, key players are continuously involved in the launch of new improved products. For instance, Perkin Elmer offers a wide portfolio of platforms for detection, handling, and analysis of spheroids. Researchers have developed mini lungs to study the mechanism of the entry of SARS-CoV-2 and its spread in tissues. Organoids have also been employed to study the defense mechanism of tissues against SARS-CoV-2. This can potentially help in the development of a vaccine for treatment.

List of Key Players of Organoids And Spheroids Market

• 3D Biomatrix
• 3D Biotek LLC
• AMS Biotechnology (Europe) Limited
• ATCC
• Cellesce Ltd.
• Corning Incorporated
• Greiner Bio-One
• Hubrecht Organoid Technology (HUB)
• InSphero/Perkin Elmer
• Kuraray
• Lonza